In line with its Science and Innovation Strategy, FAO has developed this guidance on strengthening science–policy interfaces (SPIs) for agrifood systems at the national level, helping to ensure that effective policy decisions are made based upon sufficient, relevant, and credible science and evidence. It is targeted to SPIs that are focused on the transformation of agrifood systems to contribute to the achievement of the SDGs, with a focus on the needs of low- and middle-income countries.